(2R)-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}(phenyl)ethanoic acid
Fmoc-L-alpha-phenylglycine
CAS: 102410-65-1
Molecular Formula: C23H19NO4
(2R)-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}(phenyl)ethanoic acid - Names and Identifiers
| Name | Fmoc-L-alpha-phenylglycine |
| Synonyms | Fmoc-Phg-OH Fmoc-L-phenylglycine FMoc-(S)-phenylglycine Fmoc-L-alpha-phenylglycine (S)-Fmoc-2-aminophenylacetic acid FMoc-Phg-OH FMoc-L-phenylglycine N-Fmoc-L-2-phenylglycineFmoc-Phg-OH [(9H-Fluoren-9-ylmethoxycarbonylamino)]phenylacetic acid (3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}phenyl)acetic acid (2R)-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}(phenyl)ethanoic acid (2S)-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}(phenyl)ethanoic acid (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-2-phenylacetic acid |
| CAS | 102410-65-1 |
| EINECS | 1533716-785-6 |
| InChI | InChI=1/C23H19NO4/c25-22(26)13-15-6-5-7-16(12-15)24-23(27)28-14-21-19-10-3-1-8-17(19)18-9-2-4-11-20(18)21/h1-12,21H,13-14H2,(H,24,27)(H,25,26) |
(2R)-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}(phenyl)ethanoic acid - Physico-chemical Properties
| Molecular Formula | C23H19NO4 |
| Molar Mass | 373.4 |
| Density | 1.299±0.06 g/cm3(Predicted) |
| Melting Point | 175-180°C |
| Boling Point | 606.3±50.0 °C(Predicted) |
| Specific Rotation(α) | 81 º (c=1% in DMF) |
| Flash Point | 291.103°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White crystal |
| Color | White to Almost white |
| BRN | 5309005 |
| pKa | 3.39±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 81 ° (C=1, DMF) |
| MDL | MFCD00155632 |
(2R)-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}(phenyl)ethanoic acid - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 2924 29 70 |
| Hazard Class | IRRITANT |
(2R)-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}(phenyl)ethanoic acid - Introduction
Fmoc-L-Phenylglycine is a compound with the chemical formula C28H22N2O5 and a molecular weight of 470.49g/mol. It is an organic amine acid derivative and has important application value.
Fmoc-L-Phenylglycine is commonly used in solid-phase synthesis as part of a synthetic polypeptide chain. It can be synthesized by a solid phase amino acid synthesis method. Solid phase synthesis is a commonly used method of peptide synthesis, in which the amino acids are sequentially fixed on the solid phase material, and the chemical reaction is repeated to construct the polypeptide chain step by step. Fmoc-L-phenylglycine is one of the selective protecting groups (protective group), which can protect the reactivity of the amino group during the synthesis.
For safety information, Fmoc-L-phenylglycine should be stored under dry, dark, low temperature conditions. During operation, attention should be paid to avoid contact with skin and eyes, and good laboratory operating habits and personal protective measures should be maintained. If inhaled, ingested, or in contact with skin, consult a doctor and bring the appropriate Chemical Safety Data Sheet (CSDS).
To sum up, Fmoc-L-phenylglycine is an organic amine acid derivative commonly used in solid-phase synthesis, which has important application value. In chemical synthesis, attention should be paid to safe use and correct operating procedures should be followed.
Fmoc-L-Phenylglycine is commonly used in solid-phase synthesis as part of a synthetic polypeptide chain. It can be synthesized by a solid phase amino acid synthesis method. Solid phase synthesis is a commonly used method of peptide synthesis, in which the amino acids are sequentially fixed on the solid phase material, and the chemical reaction is repeated to construct the polypeptide chain step by step. Fmoc-L-phenylglycine is one of the selective protecting groups (protective group), which can protect the reactivity of the amino group during the synthesis.
For safety information, Fmoc-L-phenylglycine should be stored under dry, dark, low temperature conditions. During operation, attention should be paid to avoid contact with skin and eyes, and good laboratory operating habits and personal protective measures should be maintained. If inhaled, ingested, or in contact with skin, consult a doctor and bring the appropriate Chemical Safety Data Sheet (CSDS).
To sum up, Fmoc-L-phenylglycine is an organic amine acid derivative commonly used in solid-phase synthesis, which has important application value. In chemical synthesis, attention should be paid to safe use and correct operating procedures should be followed.
Last Update：2024-04-10 22:29:15
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